Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T3146 |
BMS-202
PD1-PDL1 inhibitor 2,PD-1/PD-L1 inhibitor 2 |
Apoptosis; PD-1/PD-L1 | Apoptosis; Cell Cycle/Checkpoint; Immunology/Inflammation |
BMS-202 (PD1-PDL1 inhibitor 2) 是一种非肽类 PD-1/PD-L 复合物抑制剂,其 IC50为 18 nM,KD 为 8 μM。它与 PD-L1 直接结合并阻断人类 PD-1/PD-L 的相互作用,具有抗肿瘤活性。 | |||
T68409 |
SHP244
|
||
SHP244 is an allosteric inhibitor of SHP2 with modest thermal stabilization of the enzyme. | |||
T61858 | HDAC8-IN-3 | ||
HDAC8-IN-3 (compound P19) is a highly potent inhibitor of HDAC8, displaying an IC50 value of 9.3 μM and producing thermal stabilization. Moreover, HDAC8-IN-3 exhibits cytotoxicity and induces apoptosis specifically in leukemic cell lines [1]. |